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Orbital peripheral T-cell lymphoma in a child
Adam S Hassan1, Victor M Elner
1Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan 48105, USA.
Ophthalmic Plastic and Reconstructive Surgery
|October 20, 2005
Summary
A rare case of orbital peripheral T-cell lymphoma with subpanniculitic features was diagnosed in a child. The patient successfully responded to radiation and chemotherapy, highlighting treatment efficacy.
Area of Science:
- Oncology
- Ophthalmology
- Pathology
Background:
- Peripheral T-cell lymphoma (PTCL) is a group of aggressive non-Hodgkin lymphomas.
- Orbital involvement by PTCL is uncommon, particularly with subpanniculitic features.
Observation:
- A 6-year-old boy presented with progressive left periorbital swelling.
- CT scans suggested an abscess or necrosis in the orbital region.
- Biopsy confirmed PTCL with necrosis of the lacrimal gland and surrounding orbital tissue.
Findings:
- Immunohistochemical and T-cell receptor gene rearrangement studies confirmed PTCL.
- The case exhibited unique subpanniculitic features within the orbit.
- The patient showed a positive response to treatment.
Implications:
- This case represents the first pathologically confirmed instance of orbital PTCL with subpanniculitic features.
- Early diagnosis and multimodal treatment (radiation and chemotherapy) are crucial for managing orbital PTCL.
- Further research into PTCL with orbital and subpanniculitic involvement is warranted.