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Interventions for treating collagenous colitis.

N Chande, J W D McDonald, J K Macdonald

    The Cochrane Database of Systematic Reviews
    |October 20, 2005
    PubMed
    Summary
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    Budesonide effectively treats collagenous colitis, a cause of chronic diarrhea. Evidence for other treatments like bismuth subsalicylate is less conclusive, requiring further research.

    Area of Science:

    • Gastroenterology
    • Clinical Pharmacology

    Background:

    • Collagenous colitis is a recognized cause of chronic diarrhea.
    • Current treatment strategies lack robust evidence from randomized trials.

    Purpose of the Study:

    • To identify effective therapies for collagenous colitis based on randomized controlled trials.
    • To evaluate treatments for patients with active collagenous colitis.

    Main Methods:

    • Systematic review of randomized trials published between 1970 and June 2005.
    • Searched MEDLINE, PubMed, Cochrane registers, and meeting abstracts.
    • Data extraction and analysis using chi-square tests and Peto odds ratios.

    Main Results:

    • Budesonide demonstrated significant clinical and histological improvement (pooled OR 12.32, NNT=2).

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  • Bismuth subsalicylate showed significant clinical and histological improvement (p=0.003).
  • Prednisolone showed a trend towards clinical response (p=0.064), while Boswellia serrata extract did not show significant improvement (p=0.32).

    • Conclusions:

    • Budesonide is an effective treatment for collagenous colitis.
    • Bismuth subsalicylate shows promise, but requires further investigation.
    • The efficacy of prednisolone and Boswellia serrata extract remains uncertain.