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Updated: Aug 14, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Segmental cutaneous hemangioma and spinal arteriovenous malformation (Cobb syndrome). Case report and historical
Boby V Maramattom1, Aaron A Cohen-Gadol, Eelco F M Wijdicks
1Department of Neurology, Mayo Clinic College of Medicine and Mayo Foundation, Rochester, Minnesota, USA.
Abstract:
The discovery of either a dermatomal cutaneous nevus or a spinal arteriovenous malformation (AVM) should raise the suspicion of Cobb syndrome. The Cobb syndrome is a neurocutaneous syndrome in which there are metameric cutaneous and spinal AVMs. The authors present the case of a patient with acute cervical myelopathy and subtle cutaneous hemangiomas in whom a cervical perimedullary fistula was discovered. They also acknowledge Harvey Cushing's contribution to the recognition of this syndrome.

