Related Experiment Video
Updated: Aug 15, 2026
Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
Published on: March 23, 2022
[Laboratory diagnosis of antiphospholipid syndrome]
1Service d'Hématologie Biologique, Hôpital Européen Georges-Pompidou, 20-40, rue Leblanc, 75908 Paris cedex 15, France. luc.darnige@hop.egp.ap-hop-paris.fr
Purpose:
The antiphospholipid syndrome is a bioclinical entity defined by the occurrence of thromboses, and/or obstetrical complications in the persistent presence of antiphospholipid antibodies, i.e. lupus anticoagulant and/or anticardiolipin antibodies. This review focuses on the methods for antiphospholipid antibodies detection and their clinical usefulness.
Current Knowledge And Key Points:
Lupus anticoagulant is the strongest risk factor for thrombosis in antiphospholipid syndrome. Twenty years after its description, anticardiolipin ELISA, despite a still improvable standardization and its lack of specificity, is still required for sensitive diagnosis of antiphospholipid syndrome.
Future Prospects And Projects:
A better knowledge of the beta-2-glycoprotein-I role in the pathophysiology of antiphospholipid syndrome might lead to the development of new markers of thrombotic risk.
