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Updated: Apr 10, 2026

Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
Published on: August 24, 2011
Spontaneous soft tissue hematomas
A Dohan1, L Darnige2, M Sapoval3
1Université Paris-Diderot, 10, rue de Verdun, 75010 Paris, France; Inserm U965, French National Institute for Health and Medical Research Unit 965, France; Assistance publique-Hôpitaux de Paris, Hôpital Lariboisière, Visceral and Vascular Radiology Department, 2, rue Ambroise-Paré, 75475 Paris, France.
Abstract:
Spontaneous muscle hematomas are a common and serious complication of anticoagulant treatment. The incidence of this event has increased along with the rise in the number of patients receiving anticoagulants. Radiological management is both diagnostic and interventional. Computed tomography angiography (CTA) is the main tool for the detection of hemorrhage to obtain a positive, topographic diagnosis and determine the severity. Detection of an active leak of contrast material during the arterial or venous phase is an indication for the use of arterial embolization. In addition, the interventional radiological procedure can be planned with CTA. Arterial embolization of the pedicles that are the source of the bleeding is an effective technique. The rate of technical and clinical success is 90% and 86%, respectively.
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