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Updated: Aug 8, 2026

Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae
Published on: November 28, 2016
Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila
Freddy Radtke1, Anne Wilson, H Robson MacDonald
1Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland. freddy.radtke@isrec.unil.ch
Abstract:
The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of self-renewing systems. In this article, we review the role of Notch signaling in the hematopoietic system with particular emphasis on lymphocyte development and highlight the similarities in Notch function between Drosophila and mammalian differentiation processes. Recent studies indicating that aberrant NOTCH signaling is frequently linked to the induction of T leukemia in humans will also be discussed.
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