Related Experiment Video
Updated: Aug 14, 2026
Visualizing the Interrenal Steroidogenic Tissue and Its Vascular Microenvironment in Zebrafish
Published on: December 21, 2016
Nonclassical 3 beta-hydroxysteroid dehydrogenase deficiency: a review of our experience with 25 female patients
1Department of Pediatrics, New York Hospital-Cornell Medical Center, New York 10021.
Objective:
To report 15 new menarcheal women affected with nonclassical 3 beta-hydroxysteroid dehydrogenase deficiency (nonclassical 3 beta-HSD) and evaluation of glucocorticoid therapy in treated patients.
Design:
Diagnosis of these new patients using a standard adrenocorticotropin test. Effects of glucocorticoid therapy on clinical hormonal and sonographic features of each patient are appreciated for periods varying between 4 months and 7 1/2 years.
Setting:
All at The New York Hospital-Cornell Medical Center. The Pediatric Endocrinology Ambulatory Service; the Children's Clinical Research Center Core Laboratories; and the Department of Radiology.
Patients, Participants:
Fifteen menarcheal women (14 to 30 years of age) newly diagnosed and 10 women previously diagnosed were evaluated for symptoms of hyperandrogenism and/or irregular menses.
Main Outcome Measure(S):
Positive effect of glucocorticoid therapy on signs and symptoms, hormonal levels, and ovarian imaging.
Results:
Polycystic ovarian syndrome is noted in approximately half the cases. Glucocorticoid treatment greater than 3 months duration results in a reversal of symptoms in most cases.
