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Helicobacter pylori seroprevalence in patients with coronary artery disease

Mehmet Kanbay1, Gürden Gür, Muammer Yücel

  • 1Department of Internal Medicine, Baskent University Faculty of Medicine, 35 Sokak, 81/5, Bahcelievler, 06490 Ankara, Turkey. drkanbay@yahoo.com

Digestive Diseases and Sciences
|October 22, 2005
PubMed

Insights

Helicobacter pylori infection is not a risk factor for coronary artery disease (CAD). This study found similar H. pylori seroprevalence in CAD patients and healthy controls, suggesting no causal link.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Chronic infections are increasingly investigated as potential risk factors for cardiovascular diseases.
  • Helicobacter pylori (H. pylori) infection has been suggested as a possible contributor to coronary artery disease (CAD).

Purpose of the Study:

  • To determine the seroprevalence of H. pylori infection in patients diagnosed with coronary artery disease (CAD).
  • To evaluate whether H. pylori seropositivity is associated with an increased risk of developing CAD.

Main Methods:

  • A case-control study involving 151 patients with CAD and 149 age- and sex-matched control subjects.
  • Enzyme-linked immunosorbent assay (ELISA) immunoglobulin (Ig) G testing was used to detect H. pylori infection in all participants.

Main Results:

  • The prevalence of H. pylori infection was 60.2% in the CAD group and 57.7% in the control group.
  • Statistical analysis showed no significant difference in H. pylori infection rates between patients with CAD and the control group (P > 0.05).

Conclusions:

  • H. pylori infection does not appear to be a significant risk factor for the development of coronary artery disease.
  • Further research is warranted to validate these findings and explore other potential associations.

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