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Updated: Aug 15, 2026

Recapitulation of an Ion Channel IV Curve Using Frequency Components
Published on: February 8, 2011
Harmonic response of cellular membrane pumps to low frequency electric fields
D Nawarathna1, J H Miller, J R Claycomb
1Texas Center for Superconductivity and Department of Physics, University of Houston, Houston, Texas 77204-5002, USA.
Abstract:
We report on harmonic generation by budding yeast cells in response to a sinusoidal electric field, which is seen to be minimal when the field amplitude is less than a threshold value. Surprisingly, sodium metavanadate, an inhibitor of P-type ATPases reportedly responsible for nonlinear response in yeast, reduces the threshold field amplitude, increasing harmonic generation at low amplitudes while reducing it at large amplitudes, whereas the addition of glucose dramatically increases the production of even harmonics. Finally, a simple model is proposed to interpret the observed behavior.
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