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Related Experiment Videos

Optic nerve diffusion tensor imaging in optic neuritis.

S Anand Trip1, Claudia Wheeler-Kingshott, Stephen J Jones

  • 1NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. a.trip@ion.ucl.ac.uk

Neuroimage
|October 26, 2005
PubMed
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Diffusion tensor magnetic resonance imaging (DT-MRI) of the optic nerve reveals axonal damage in patients with prior optic neuritis. Elevated diffusivity and reduced anisotropy indicate structural changes, correlating with visual evoked potential amplitudes.

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Physics

Background:

  • Diffusion tensor magnetic resonance imaging (DT-MRI) offers insights into central nervous system pathologies.
  • Optic nerve studies using DT-MRI are valuable for understanding visual pathway integrity.
  • Previous studies lacked full diffusion tensor measurements for optic nerve analysis.

Purpose of the Study:

  • To apply a novel DT-MRI technique for full diffusion tensor measurements in the optic nerve.
  • To quantify microstructural changes in optic nerves affected by prior optic neuritis.
  • To correlate DT-MRI findings with visual function tests.

Main Methods:

  • Utilized zonal oblique multislice (ZOOM) echoplanar imaging for full diffusion tensor acquisition.
  • Segmented intraorbital nerves and analyzed mean diffusivity (MD), fractional anisotropy (FA), and eigenvalues.

Related Experiment Videos

  • Performed quantitative visual testing and electrophysiology, including visual evoked potentials (VEPs).

    • Main Results:

    • Affected optic nerves showed significantly increased MD and orthogonal eigenvalue (λ⊥) compared to contralateral and control nerves.
    • Reduced FA was observed in affected nerves, indicating axonal disruption.
    • VEP amplitude correlated significantly with MD and λ⊥, suggesting a link between structural integrity and visual function.

    Conclusions:

    • Optic nerve DT-MRI parameters, specifically MD and λ⊥, effectively indicate axonal damage after optic neuritis.
    • These findings highlight the potential of DT-MRI for assessing structural integrity in the visual pathway.
    • DT-MRI metrics provide objective measures of optic nerve pathology beyond clinical assessment.