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Does Bertrand's rule apply to macronutrients?

D Raubenheimer1, K P Lee, S J Simpson

  • 1School of Biological Sciences, Ecology Evolution and Behaviour Section, University of Auckland, Private Bag 92019, Auckland, New Zealand. d.raubenheimer@auckland.ac.nz

Proceedings. Biological Sciences
|October 26, 2005
PubMed
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Excessive carbohydrate intake can be harmful, increasing mortality in caterpillars. This finding extends Bertrand

Area of Science:

  • Nutritional science
  • Toxicology
  • Insect physiology

Background:

  • Micronutrient dose-response curves are often non-monotonic (Bertrand's rule), with benefits followed by toxicity.
  • This rule is widely assumed not to apply to caloric macronutrients due to experimental challenges.

Purpose of the Study:

  • To investigate if the toxic phase of Bertrand's rule applies to macronutrient intake.
  • To test the effects of excess carbohydrate consumption on mortality in caterpillars.

Main Methods:

  • Overcame methodological challenges in inducing macronutrient overconsumption in animals.
  • Utilized the generalist-feeding caterpillar Spodoptera littoralis as a model organism.
  • Isolated the effects of specific food components, specifically carbohydrates.

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Main Results:

  • Excessive carbohydrate intake led to increased mortality in Spodoptera littoralis.
  • Demonstrated a non-monotonic dose-response relationship for carbohydrate intake.

Conclusions:

  • Bertrand's rule, previously applied to micronutrients, can be extended to macronutrients.
  • Excessive carbohydrate consumption poses toxicological risks, impacting survival rates.