The significance of elevated CSF lactate.
S L Chow1, Z J Rooney, M A Cleary
1Metabolic Unit, Great Ormond Street Hospital for Children, London, UK.
Archives of Disease in Childhood
|October 26, 2005
Summary
Elevated cerebrospinal fluid (CSF) lactate levels in 158 patients indicated various conditions like seizures and metabolic disorders. Accurate diagnosis of congenital lactic acidoses requires measuring CSF lactate in patients free from seizures and acute illness.
Area of Science:
- Neurology
- Biochemistry
- Pediatrics
Background:
- Elevated cerebrospinal fluid (CSF) lactate concentration is a significant indicator in neurological and metabolic conditions.
- Understanding the differential diagnoses associated with high CSF lactate is crucial for effective patient management.
Purpose of the Study:
- To ascertain the final diagnoses in a cohort of patients presenting with elevated CSF lactate levels (> 2 mmol/l).
- To establish optimal conditions for diagnosing congenital lactic acidoses using CSF lactate measurements.
Main Methods:
- Retrospective analysis of 158 patients with CSF lactate > 2 mmol/l.
- Review of patient records to determine final diagnoses, including neurological, inflammatory, and metabolic conditions.
Main Results:
- The study identified seizures, inflammatory changes, and confirmed metabolic disorders as common conditions associated with elevated CSF lactate.
- Specific diagnostic criteria were considered for congenital lactic acidoses.
Conclusions:
- CSF lactate is a valuable biomarker for a range of neurological and metabolic disorders.
- For accurate diagnosis of congenital lactic acidoses, CSF lactate measurement is recommended in seizure-free patients post-acute illness.
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