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Updated: Aug 15, 2026
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Selective steroid recognition by a partially bridged resorcin[4]arene cavitand
Martina Cacciarini1, Vladimir A Azov, Paul Seiler
1Laboratorium für Organische Chemie, ETH-Hönggerberg, CH-8093 Zürich, Switzerland. martina.cacciarini@unifi.it
Abstract:
The partially bridged resorcin[4]arene cavitand featuring a cleft-shaped recognition site formed by two anti-quinoxaline bridges and four convergent HO-groups was prepared in three steps and characterised by X-ray crystallography; cavitand was found to be a selective receptor for steroidal substrates in CDCl3, with the best binding observed for steroids with a flat A-ring and two H-bonding sites on rings A and C/D.
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