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A viscometric method of measuring plasma fibrinogen concentrations
E Ernst1, K L Resch, T Saradeth
1Department of Physics Medical Rehabilitation, AKH, University of Vienna, Austria.
Journal of Clinical Pathology
|June 1, 1992
Summary
A new viscometric method accurately measures fibrinogen levels by analyzing serum viscosity compared to plasma. This technique offers a viable alternative to the Clauss method for laboratories with viscometers.
Area of Science:
- Clinical Chemistry
- Biomedical Engineering
Background:
- Accurate fibrinogen measurement is crucial for diagnosing and managing coagulation disorders.
- The Clauss method is the standard for determining plasma fibrinogen concentration.
Purpose of the Study:
- To evaluate a novel viscometric technique for measuring serum fibrinogen.
- To compare the accuracy and reproducibility of the viscometric method against the Clauss method.
Main Methods:
- Serum and plasma samples were analyzed using both the viscometric and Clauss methods.
- Correlation coefficients and reproducibility were assessed at varying fibrinogen concentrations.
Main Results:
- The viscometric method showed a high correlation with the Clauss method (r = 0.914).
- Reproducibility was comparable across different fibrinogen levels, with slight variations at low concentrations.
Conclusions:
- The viscometric method provides a reasonably accurate alternative for fibrinogen determination.
- This technique is suitable for laboratories equipped with viscometers.