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Updated: Aug 8, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
Published on: May 13, 2012
The regulation of cell migration by PTEN
N R Leslie1, X Yang, C P Downes
1Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, Scotland, UK. n.r.leslie@dundee.ac.uk
Abstract:
In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.
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