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Large cerebral artery involvement in CADASIL

Eun J Choi1, Choong G Choi, Jong S Kim

  • 1Department of Neurology, University of Korea College of Medicine, Guro Hospital, Seoul, Korea.

Neurology
|October 26, 2005
PubMed

Insights

Large cerebral artery involvement, including stenosis, was observed in 38% of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). This suggests large vessel disease can occasionally occur in CADASIL patients.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroimaging

Background:

  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary condition primarily affecting small cerebral arteries.
  • The role of large cerebral artery involvement in CADASIL pathogenesis remains less understood.

Purpose of the Study:

  • To investigate the prevalence and characteristics of large cerebral artery abnormalities in patients diagnosed with CADASIL.

Main Methods:

  • Utilized angiography, including 12 Magnetic Resonance (MR) angiograms and one conventional angiogram, to assess 13 patients with CADASIL.
  • Evaluated for the presence and location of arterial stenosis.

Main Results:

  • Angiographic abnormalities were detected in five out of 13 (38%) CADASIL patients.
  • Stenosis was identified in the middle cerebral artery (three patients), vertebral artery (one patient), and internal carotid artery (one patient).
  • Stenosis persisted in two patients upon follow-up angiography, with no significant differences in risk factors between patients with and without angiographic findings.

Conclusions:

  • Large cerebral artery involvement, specifically stenosis, can occasionally be present in patients with CADASIL.
  • These findings suggest that large vessel disease may be an under-recognized feature in some individuals with CADASIL.
  • Further research is warranted to elucidate the clinical significance and underlying mechanisms of large vessel involvement in CADASIL.

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