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Updated: Aug 8, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
A direct synthesis of pyrrolocytosine from 5-iodocytosine
R H E Hudson1, A K Dambenieks, R D Viirre
1Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
Abstract:
We have employed a tandem Sonogashira/annulation reaction between 5-iodocytosine derivatives and terminal alkynes to yield the fluorescent bicyclic nucleobase pyrrolcytosine. Pyrrolocytosine bearing substituents only on the pyrrole ring are conveniently synthesized from 5-iodocytosine. Water soluble pyrrolocytosines are being investigated as reporter groups in SNP analysis.
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