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Large-scale synthesis of 5'-O-pixyl protected 2'-deoxynucleosides useful for oligonucleotide synthesis

Robert T Day1, Dean Williams, Priscilla Soriano

  • 1RI Chemical, Inc., 632 W. Angus Ave., Orange, CA 92868, USA.

Nucleosides, Nucleotides & Nucleic Acids
|October 27, 2005
PubMed

Abstract:

Synthesis of 5'-O-pixylated 2'-deoxynucleosides 4 has been accomplished and the products are commercially available.

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Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...

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