Related Experiment Video
Updated: Aug 15, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Comparative genomics and phylogenetic analysis of S. dysenteriae subgroup
E Yang1, Wen Bin, Junping Peng
1School of Medicine, Xi'an Jiaotong University, China.
Abstract:
Genomic compositions of representatives of thirteen S. dysenteriae serotypes were investigated by performing comparative genomic hybridization (CGH) with microarray containing the whole genomic ORFs (open reading frames, ORFs) of E. coli K12 strain MG1655 and specific ORFs of S. dysenteriae A1 strain Sd51197. The CGH results indicated the genomes of the serotypes contain 2654 conserved ORFs originating from E. coli. However, 219 intrinsic genes of E. coli including those prophage genes, molecular chaperones, synthesis of specific O antigen and so on were absent. Moreover, some specific genes such as type II secretion system associated components, iron transport related genes and some others as well were acquired through horizontal transfer. According to phylogenic trees based on genetic composition, it was demonstrated that A1, A2, A8, A10 were distinct from the other S. dysenteriae serotypes. Our results in this report may provide new insights into the physiological process, pathogenicity and evolution of S. dysenteriae.
Related Concept Videos
Evolutionary Relationships through Genome Comparisons
Bacterial Gastroenteritis
Modern Molecular Taxonomy
Microbial Phylogeny
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Phylogenetic Species Concept in Microbiology
