Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chelation in root canal therapy reconsidered.

Matthias Zehnder1, Patrick Schmidlin, Beatrice Sener

  • 1Department of Preventive Dentistry, Cariology, and Periodontology, Division of Endodontics, University of Zürich Center for Dental Medicine, Zürich, Switzerland. matthias.zehnder@zzmk.unizh.ch

Journal of Endodontics
|October 27, 2005
PubMed
Summary

This study investigated chelator interactions with sodium hypochlorite (NaOCl) in endodontics. While EDTA and citric acid reduced NaOCl efficacy, HEBP showed no negative interference, preserving antimicrobial capacity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Salivary biomarker profiling in prediabetes-associated periodontitis: role of adiponectin, resistin, and total matrix metalloproteinase-8.

Frontiers in dental medicine·2026
Same author

Physico-chemical analysis of eight pre-mixed hydraulic silicate sealers.

Frontiers in dental medicine·2026
Same author

Dissolution versus dislodgment of dentin debris by pulsed erbium-doped yttrium aluminum garnet laser-activated endodontic irrigants.

Lasers in medical science·2026
Same author

The Effect of Mechanical Instrumentation on Dental Hard Tissue In Vitro: A Systematic Review.

International journal of dental hygiene·2026
Same author

Low bone density and periodontal disease in postmenopausal women: A systematic review and meta-analysis.

Journal of family medicine and primary care·2026
Same author

Impact of diabetes mellitus on dental pulp tissue pathosis - A scoping review.

Diabetes & metabolic syndrome·2026

Area of Science:

  • Endodontics
  • Dental Materials Science
  • Biochemistry

Background:

  • Sodium hypochlorite (NaOCl) is a crucial endodontic irrigant.
  • Chelating agents like EDTA and citric acid (CA) are used in endodontics.
  • Potential interactions between NaOCl and chelators can affect treatment efficacy.

Purpose of the Study:

  • To evaluate the interactions between NaOCl and common chelators (EDTA, CA).
  • To assess alternative chelators (STP, ATMA, HEBP) for compatibility with NaOCl.
  • To determine the impact of these interactions on NaOCl's antimicrobial activity.

Main Methods:

  • Titration of available chlorine in chelator-NaOCl solutions.
  • Atomic absorption spectrometry and SEM analysis of root canal walls.

Related Experiment Videos

  • Antimicrobial capacity testing of chelator-NaOCl mixtures.

    • Main Results:

    • EDTA and CA caused immediate and significant loss of available chlorine from NaOCl.
    • HEBP and STP showed minimal interference with NaOCl's available chlorine.
    • NaOCl did not negatively affect the calcium-complexing ability of the tested chelators.
    • EDTA and CA reduced the antimicrobial efficacy of NaOCl, whereas HEBP did not.

    Conclusions:

    • EDTA and CA interfere with NaOCl's chemical and antimicrobial properties.
    • HEBP is a compatible chelator for use with NaOCl in endodontic procedures.
    • HEBP represents a promising alternative for chelating action during endodontic treatment.