[Neuroretinitis, Parry-Romberg syndrome, and scleroderma]

Area of Science:

• Ophthalmology
• Neurology
• Genetics

Background:

• Progressive hemifacial atrophy (Parry-Romberg syndrome) is a rare disorder characterized by progressive atrophy of facial tissues.
• Ocular and neurological symptoms are common, with enophthalmos and eyelid changes being most frequent.
• Neuroretinitis is a rare manifestation of Parry-Romberg syndrome.

Observation:

• A 22-year-old woman presented with a 10-year history of progressive hemifacial atrophy.
• She experienced blurred vision, mild enophthalmos, eyelid atrophy, and loss of cilia.
• Ocular examination revealed bilateral vitreitis and neuroretinitis in the left eye.

Findings:

• Etiological investigations detected antinuclear antibodies and a positive Rose-Waaler latex test.
• The patient exhibited atrophy on the right side of her body.
• Corticosteroid therapy (1 mg/kg/day) was initiated with positive outcomes.

Implications:

• This case underscores the diverse ophthalmologic manifestations of Parry-Romberg syndrome.
• The etiology of Parry-Romberg syndrome remains controversial, with potential links to scleroderma and autonomic nervous system disorders.
• The pathogenesis of acute neuroretinitis in this context requires further investigation.