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Diffuse leptomeningeal involvement by a ganglioglioma in a child. Case report
M R Wacker1, P H Cogen, J E Etzell
1Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
Journal of Neurosurgery
|August 1, 1992
Abstract:
Gangliogliomas are tumors composed of neuronal and glial elements that typically grow slowly by expansion only. This report describes a 20-month-old girl with a ganglioglioma that extensively involved the subarachnoid space; microscopic foci of tumor were found in the brain and spinal cord. Despite chemotherapy and radiation therapy, the child died 5 months after diagnosis. Molecular genetic analysis showed loss of chromosome 17p DNA sequences in the tumor tissue.