Related Experiment Videos
Corticotropin-releasing factor binding protein--a ligand trap?
Olaf Jahn1, Jelena Radulovic, Oliver Stiedl
1Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Goettingen, Germany.
Mini Reviews in Medicinal Chemistry
|October 28, 2005
Summary
Corticotropin-releasing factor binding protein (CRFBP) inhibitors may treat cognitive deficits by releasing memory-enhancing corticotropin-releasing factor (CRF). This review explores CRFBP inhibitors
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Corticotropin-releasing factor (CRF) is a neuropeptide with memory-enhancing effects.
- CRF's actions are regulated by corticotropin-releasing factor binding protein (CRFBP).
Purpose of the Study:
- To review recent advances in CRFBP inhibitors.
- To focus on the pharmaceutical potential of CRFBP inhibitors for cognitive deficits.
Main Methods:
- Literature review of recent advances in CRFBP inhibitor research.
Main Results:
- CRFBP inhibitors can release endogenous CRF.
- This release is a potential therapeutic strategy for cognitive deficits.
Conclusions:
- CRFBP inhibitors show promise for treating cognitive impairments.
- Further research into their pharmaceutical potential is warranted.