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Preparation and stability of intravenous solutions of sodium dichloroacetate (DCA)
P I Chu1, S H Curry, T G Baumgartner
1University of Florida, Gainesville.
Journal of Parenteral Science and Technology : a Publication of the Parenteral Drug Association
|January 1, 1992
Abstract:
An IV injection formulation of sodium dichloroacetate (DCA) was prepared without heat sterilization, and examined for stability. DCA is heat labile in aqueous solutions. Its decomposition involves dehalogenation and production of hydrogen ions. Decomposition occurs relatively rapidly at relatively low pH values, and is promoted by heating. Injection solutions should be prepared aseptically and sterilized by filtration. Solutions prepared aseptically and sterilized by filtration are stable stored at 4 degrees C for at least four yrs.