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Dietary components modify gene expression: implications for carcinogenesis.

Kan Yang1, Wancai Yang, John Mariadason

  • 1Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10467, USA.

The Journal of Nutrition
|October 28, 2005
PubMed
Summary
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Diet significantly impacts intestinal tumor development. A Western-style diet high in fat and low in calcium and vitamin D accelerates tumor formation in mouse models, highlighting diet

Area of Science:

  • Gastroenterology and Hepatology
  • Oncology
  • Nutritional Science

Background:

  • Mouse genetic models reveal insights into intestinal cell maturation and tumor formation mechanisms.
  • Epidemiological and experimental data strongly suggest diet is a key factor in tumor development risk.

Purpose of the Study:

  • To investigate the impact of a Western-style diet on tumor formation in genetically modified mouse models.
  • To explore how calcium and vitamin D levels influence intestinal tumor development.
  • To analyze gene expression profiles to understand dietary effects on metabolic and regulatory pathways.

Main Methods:

  • Utilized mouse genetic models with manipulated genes (Apc, p21(WAF1/cip1), p27(Kip1)).
  • Administered a Western-style diet (high fat, low calcium, low vitamin D).

Related Experiment Videos

  • Modulated calcium and vitamin D levels in diet and mouse models.
  • Analyzed gene expression profiles of intestinal mucosa.

    • Main Results:

    • A Western-style diet significantly increased and accelerated tumor formation in genetic mouse models.
    • Dietary modulation of calcium and vitamin D levels substantially influenced tumor formation.
    • Gene expression analysis revealed dietary impacts on metabolic profiles and regulatory pathways in normal intestinal mucosa.

    Conclusions:

    • Diet, particularly a Western-style pattern, plays a critical role in accelerating intestinal tumor formation, even in genetically susceptible mice.
    • Calcium and vitamin D are key dietary components that can modulate intestinal cancer development.
    • Dietary interventions targeting metabolic and regulatory pathways offer potential strategies for preventing sporadic colon cancer.