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Updated: Feb 11, 2026

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface
Published on: July 21, 2016
Gene expression microarray data analysis of decidual and placental cell differentiation.
Sue Kong1, Bruce J Aronow, Stuart Handwerger
1Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
DNA microarray analysis reveals gene expression patterns in cellular differentiation and responses to various stimuli. This chapter details methods for analyzing this data to understand biological significance and classify gene functions.
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- DNA microarray technology offers powerful insights into cellular physiology and pathophysiology.
- Gene expression profiling is crucial for understanding biological processes like differentiation and responses to external factors.
- Analyzing complex gene expression data requires robust methodologies.
Purpose of the Study:
- To present methods for analyzing DNA microarray data.
- To illustrate the detection and analysis of gene expression patterns in cellular differentiation.
- To demonstrate the classification of regulated genes into functional categories and pathways.
Main Methods:
- Utilizing DNA microarray approaches for gene expression analysis.
- Applying established laboratory investigations as case studies.
- Developing and applying methods for data analysis and biological interpretation.
Main Results:
- Successfully detected and analyzed gene expression patterns related to cellular differentiation.
- Classified regulated genes into relevant functional categories and biological pathways.
- Demonstrated the biological significance of identified gene expression patterns.
Conclusions:
- DNA microarray data analysis provides significant biological insights.
- Methodologies presented enable effective detection and interpretation of gene expression patterns.
- This approach aids in understanding complex biological systems and responses.
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