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Common variable immunodeficiency (CVID) presenting with malabsorption due to giardiasis.

Kevser Onbaşi1, Fulya Günşar, Aytül Z Sin

  • 1Department of Internal Medicine, Division of Immunology, Medical Faculty, Yüzüncü Yil University, 65040 Van, Turkey. kevseronbasi@yahoo.com

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|October 28, 2005
PubMed
Summary

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Common variable immunodeficiency (CVID) can cause chronic diarrhea and recurrent infections. Early diagnosis and treatment with immunoglobulin therapy can resolve gastrointestinal issues and improve patient health.

Area of Science:

  • Immunology
  • Gastroenterology

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by B-cell and T-cell dysfunction, leading to hypogammaglobulinemia.
  • Patients often experience recurrent bacterial infections and gastrointestinal complications.

Observation:

  • A 39-year-old woman presented with a year of chronic, non-bloody diarrhea and significant weight loss.
  • Her medical history included recurrent respiratory infections since childhood, and low serum immunoglobulin levels.
  • Endoscopic examination revealed duodenal nodularity, with biopsies confirming Giardia lamblia infection.

Findings:

  • The patient was diagnosed with common variable immunodeficiency (CVID).
  • Treatment with metronidazole and intravenous immunoglobulin (IVIG) resolved her chronic diarrhea and led to weight recovery.

Related Experiment Videos

  • Giardiasis was identified as the cause of her gastrointestinal symptoms, potentially exacerbated by CVID.

    • Implications:

    • This case highlights the importance of considering CVID in patients with unexplained chronic diarrhea, especially those with a history of recurrent infections.
    • Gastrointestinal manifestations, such as giardiasis, are common in CVID and can be effectively managed with appropriate therapy.
    • Prompt diagnosis and treatment of CVID and its associated infections are crucial for improving patient outcomes and quality of life.