[Natural killers and biogenic amines: the paracrine regulation in the immune system]

Natural killers are referred to the category of cells well known for their assistance in cyto-differentiation control. Mechanisms of such assistance include cytolytic and secretory effects on the target. In this aspect, the NK capacity to assist in local aminoregulatory processes by adrenalin, serotonin, histamine release contained in these cells granules is considered to be the least studied and the most problematic issue. The solution of this problem demands taking into consideration a number of conditions: the NK ability to receipt biogenic amines and peculiarities of receptor structure; principal differences in mechanism of action of biogenic amines which enter the cell through exogenous pathway or which are synthesized endogenously; correlation between biogenic amines presence in the granules and functional NK state. Hypothesis of generation connected with the problem suggests the NK assistance in cytolysis in concomitant mechanisms of paracrine regulation of cellular microenvironmental proliferative response, induction of local inflammatory and immunomodulating processes.