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[Experimental study of Oleanolic acid liquid acting on climacteric rats]
Yan Lou1, Zhiliang Chen, Chunxia Wang
1Nanfang Hospital, Southern Medical University, Guangzhou 510515.
Objective:
To study whether the Oleanolic acid had curative effect on climacteric rats as an independent factor.
Methods:
The experimental group was administrated with Oleanolic acid, while the positive group was given with Isoflavniphytoestrogeno, and the climacteric model and adolescent control groups were fed with 0.9% saline water. The effect of Oleanolic acid on rats was observed. In each group the levels of serum E2, SOD, MDA, GSH-Px were tested, the morphology of ovary and adrenal cortex were also studied.
Results:
It was showed that Oleanolic acid could increase the levels of serum E2, SOD, GSH-Px (P < 0.05), decrease the level of MDA (P < 0.01) and improve the morphology and the functions of ovary and adrenal cortex.
Conclusions:
It is concluded that Oleanolic acid has curative effect independently on climacteric rats.
