Related Experiment Video
Updated: Aug 15, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
Published on: October 24, 2025
An emerging role for PtdIns(4,5)P2-mediated signalling in human disease
Jonathan R Halstead1, Kees Jalink, Nullin Divecha
1Department of Cellular Biochemistry, the Netherlands Cancer Institute, AvL ziekenhuis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. j.halstead@nki.nl
Abstract:
Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2) appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome.
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
PI3K/mTOR/AKT Signaling Pathway
IP3/DAG Signaling Pathway
The JAK-STAT Signaling Pathway
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
