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Mild bleeding disorders. A clinical and laboratory study
J D Parkin1, I L Smith, A I O'Neill
1Haematology Department, Repatriation General Hospital, Heidelberg West, VIC.
The Medical Journal of Australia
|May 4, 1992
Summary
In vitro testing revealed abnormal haemostasis in over half of patients with mild bleeding disorders. Easy bruising is a significant indicator of underlying in vitro test abnormalities.
Area of Science:
- Hematology
- Clinical Pathology
Background:
- Mild bleeding disorders present with diverse symptoms.
- Accurate diagnosis relies on comprehensive in vitro testing.
Purpose of the Study:
- To evaluate in vitro haemostasis in individuals with symptoms suggestive of mild bleeding disorders.
- To compare laboratory test results with a healthy reference group.
Main Methods:
- Prospective study of 93 consecutive patients referred from community and hospital settings.
- Unselective application of an extensive range of in vitro haemostasis tests.
- Exclusion of severely ill hospital patients.
Main Results:
- Abnormal in vitro test results were observed in 53% of subjects.
- Prolonged bleeding time occurred in 13%, often with other abnormal tests.
- Von Willebrand's disease diagnosed in 7% of patients.
Conclusions:
- Abnormal in vitro test results are prevalent in patients with mild bleeding disorder symptoms.
- Easy bruising is a significant clinical feature associated with abnormal in vitro findings.
- Comprehensive laboratory evaluation is crucial for diagnosing mild bleeding disorders.