Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional activation imaging in aging and dementia.

David Prvulovic1, Vincent Van de Ven, Alexander T Sack

  • 1Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe-Universität, Heinrich-Hoffmann-Str. 10, 60528 Frankfurt, Germany. prvulovic@em.uni-frankfurt.de

Psychiatry Research
|November 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stimulation priming and psychological state shape functional connectivity following prefrontal theta-burst stimulation.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

EEG biomarkers of accelerated prolonged intermittent theta-burst stimulation in depression: Machine learning with a minimal-electrode montage.

Brain stimulation·2026
Same author

Altered EEG microstate dynamics as a neurophysiological biomarker for diagnostic differentiation in Schizophrenia.

Psychiatry research. Neuroimaging·2026
Same author

Causal interhemispheric neuromodulation sharpens synaptic and neurobehavioral inhibition in stroke.

Brain communications·2026
Same author

Task-based fNIRS biomarkers of HD-tDCS treatment for negative symptoms in schizophrenia.

Schizophrenia research·2026
Same author

Improving the Transcranial Magnetic Stimulation Experience: How Transcranial Magnetic Stimulation Parameters and Coil Design Affect Somatosensory Sensations.

Neuromodulation : journal of the International Neuromodulation Society·2026

As people live longer, understanding neurodegeneration

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Increasing life expectancy highlights the impact of neurodegeneration on brain function.
  • Tools are needed to study neurodegenerative processes and compensatory mechanisms over time.
  • Comparing brain activation across aging and dementia stages is crucial.

Purpose of the Study:

  • To investigate brain activation patterns in Alzheimer's disease (AD) and healthy aging.
  • To understand if general rules govern functional brain changes during neurodegeneration and compensation.
  • To integrate findings from studies across different neurodegenerative stages.

Main Methods:

  • Review of functional activation studies in healthy aging, at-risk individuals, mild cognitive impairment (MCI), and AD patients.

Related Experiment Videos

  • Analysis of existing theoretical models of functional activation changes.
  • Proposal of an integrative account for neural response patterns.

    • Main Results:

    • Brain activation patterns vary with the stage of neurodegeneration.
    • Compensatory mechanisms play a role in neural responses.
    • Different amounts of neuronal damage and pathway recruitment lead to distinct patterns.

    Conclusions:

    • An integrative model explains functional brain changes across the spectrum of aging and dementia.
    • Understanding these patterns is key to developing tools for monitoring neurodegeneration.
    • This research provides insights into the dynamic nature of brain function under neurodegenerative stress.