Immunocytochemical localization of beta thyroid receptor in the rat cerebellum

Using a specific antibody, we report here the immunocytochemical localization of the beta thyroid receptor (TR beta) in the adult rat cerebellum. We show that the immunoreactivity is specifically located in the Purkinje cells while the internal granular layer and the molecular layer are devoid of staining. In Purkinje cells, the immunoreactivity is either limited in the nuclei, or predominantly located in the perinuclear region and the cytoplasm. The presence of thyroid receptor is correlated with the presence of TR beta mRNAs as determined by Northern analysis.