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Published on: March 18, 2019
[Lethal anaphylactic shock model induced by human mixed serum in guinea pigs]
Guang-Mu Ren1, Ji-Wei Bai, Cai-Rong Gao
1Department of forensic medicine,Shanxi Medical University, Taiyuan 030001, China. renguangmu@163.com
Objective:
To establish an anaphylactic shock model induced by human mixed serum in guinea pigs.
Methods:
Eighteen guinea pigs were divided into two groups: sensitized and control, The sensitized group were immunized intracutaneously with human mixed serum and then induced by endocardiac injection after 3 weeks.
Results:
Symptoms of anaphylactic shock appeared in the sensitized group. The level of serum IgE were increased in the sensitized group significantly.
Conclusions:
An animal model of anaphylactic shock wer established successfully. It provide a tool for both forensic study and anaphylactic shock therapy.
