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Related Experiment Videos

Fast-melting tablets based on highly plastic granules.

Yourong Fu1, Seong Hoon Jeong, Kinam Park

  • 1Akina Inc., West Lafayette, IN 47906, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|November 2, 2005
PubMed
Summary
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New highly plastic granules were developed for creating fast-melting tablets (FMTs) using a simple compression method. These porous, three-component granules ensure tablets dissolve quickly while maintaining structural integrity for packaging.

Area of Science:

  • Pharmaceutical technology
  • Materials science

Background:

  • Fast-melting tablets (FMTs) offer improved patient compliance, especially for pediatric and geriatric populations.
  • Traditional manufacturing methods for FMTs can be complex and costly.

Purpose of the Study:

  • To develop highly plastic granules for efficient manufacturing of fast-melting tablets (FMTs) via compression.
  • To investigate the properties of these granules and their impact on tablet characteristics.

Main Methods:

  • Development of three-component granules: a plastic material, a water penetration enhancer, and a wet binder.
  • Compression of these granules into tablets at low pressure.
  • Evaluation of granule porosity, tablet strength, and friability.

Main Results:

Related Experiment Videos

  • The developed granules maintained a porous structure post-compression.
  • The porous and plastic nature facilitated rapid water absorption and tablet dissolution.
  • Prepared tablets exhibited suitable strength and friability for multi-tablet packaging.

Conclusions:

  • Highly plastic granules offer an effective compression-based method for producing fast-melting tablets.
  • The unique granule composition enables rapid dissolution while ensuring tablet integrity.
  • This approach simplifies FMT manufacturing and enhances product suitability for packaging.