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Updated: Aug 15, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
Synthesis and biological evaluation of 1beta-methylcarbapenems having guanidino moieties
Chang-Hyun Oh1, Jung-Hyuck Cho
1Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul 130-650, South Korea. choh@kist.re.kr
Abstract:
The synthesis of a new series of 1beta-methylcarbapenems having the substituted guanidinocarbonyl pyrrolidine moieties is described. Their in vitro antibacterial activities against both Gram-positive including MRSA and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. In particular, the compound Ib having piperazinylguanidine moiety showed the most potent antibacterial activity.
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