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Clinical features of chronic pancreatitis in Korea: a multicenter nationwide study
Ji Kon Ryu1, Jun Kyu Lee, Yong-Tae Kim
1Korean Multicenter Study Group on Chronic Pancreatitis, Division of Gastroenterology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu, Korea.
Insights
Alcohol is the leading cause of chronic pancreatitis (CP) in Korea, with diabetes and pseudocysts being common complications, particularly in alcoholic cases. Pancreatic cancer also developed in a notable percentage of patients.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Epidemiology
Background:
- Limited nationwide clinical data on chronic pancreatitis (CP) in Korea.
- Need for understanding CP etiology and clinical features in the Korean population.
Purpose of the Study:
- Investigate the primary causes and clinical characteristics of chronic pancreatitis (CP) in Korea.
- Analyze the prevalence of symptoms, complications, and surgical interventions in CP patients.
Main Methods:
- Retrospective analysis of 814 chronic pancreatitis (CP) cases over four years.
- Data collected from 13 tertiary hospitals across Korea.
- Information gathered included etiology, symptoms, complications, and surgical history.
Main Results:
- Alcohol identified as the predominant cause of CP (64.3%), followed by idiopathic CP (20.8%).
- Common complications included diabetes (31.6%) and pseudocysts (28.4%), more frequent in alcoholic CP.
- Pancreatic cancer developed in 3.1% of patients during follow-up.
Conclusions:
- Alcohol is the primary etiological factor for chronic pancreatitis (CP) in Korea.
- Diabetes and pseudocysts are significant complications, especially in alcoholic CP.
- The incidence of pancreatic cancer in CP patients warrants further attention.
Background/Aims:
No reliable nationwide clinical data about chronic pancreatitis (CP) was available in Korea. The etiology and clinical features of CP were investigated using a multicenter nationwide study.
Methods:
814 cases of CP were enrolled retrospectively over the past 4 years at 13 hospitals. The following data were obtained from all patients: etiology, symptoms, complications, and surgery.
Result:
Alcohol (64.3%) was the major cause of CP and idiopathic CP (20.8%) was the second most common form. Mean patient age was 50.6 years and the male:female ratio was 6:1 (24:1 for alcoholic CP vs. 2:1 in idiopathic CP, p < 0.001). Diabetes (31.6%), pseudocysts (28.4%), biliary stricture (13.9%), and pancreatic ascites (6.6%) were the main complications. Of these, diabetes (35 vs. 26%) and pseudocyst (33.7 vs. 21.9%) were more frequent in alcoholic than in idiopathic CP. Pancreatic cancer developed in 25 patients (3.1%) during follow-up and their mean age was 59.1 years.
Conclusions:
In Korea, alcohol is the most common etiology of CP. Moreover, diabetes and pseudocysts are frequent complications, especially in alcoholic CP, and pancreatic cancer development is not infrequent.
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