Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reconstructing immune phylogeny: new perspectives.

Gary W Litman1, John P Cannon, Larry J Dishaw

  • 1Department of Pediatrics, University of South Florida College of Medicine, All Children's Hospital Children's Research Institute, 830 First Street South, Saint Petersburg, Florida 33701, USA. litmang@allkids.org

Nature Reviews. Immunology
|November 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redefinition of the toll-like receptor repertoire in <i>Ciona robusta</i> through genomic, structural, and expression analyses.

Frontiers in cellular and infection microbiology·2026
Same author

Draft genome sequence of <i>Gracilimonas</i> sp. strain BCB1 isolated from the gill tissue of the lucinid bivalve <i>Stewartia floridana</i> in Pinellas County, Florida, USA.

Microbiology resource announcements·2025
Same author

Distribution of microsporidia in preterm and full-term infant gut microbiomes and implications for host health.

Frontiers in pediatrics·2025
Same author

Prophage regulation of <i>Shewanella fidelis</i> 3313 motility and biofilm formation with implications for gut colonization dynamics in <i>Ciona robusta</i>.

eLife·2025
Same author

<i>Pseudovibrio ascidiaceicola</i> 5337, a marine bacterial symbiont of the ascidian gut with unusual genome features.

Microbiology resource announcements·2025
Same author

Associations of Microbial Diversity with Age and Other Clinical Variables among Pediatric Chronic Rhinosinusitis (CRS) Patients.

Microorganisms·2023
Same journal

A guide to CAR T cell therapies: development, current status and future prospects.

Nature reviews. Immunology·2026
Same journal

Macrophages in embryonic development.

Nature reviews. Immunology·2026
Same journal

Glycolytic capacity instructs tumour vasculature and response to immunotherapy.

Nature reviews. Immunology·2026
Same journal

Vaginal NK cells limit epithelial barrier disruption during infection.

Nature reviews. Immunology·2026
Same journal

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same journal

T cell engagers in autoimmune diseases.

Nature reviews. Immunology·2026
See all related articles

The study reveals that the evolution of immune systems across diverse species highlights varied strategies for host protection. It emphasizes a broad spectrum of immune recognition mechanisms beyond traditional adaptive and innate immunity distinctions.

Area of Science:

  • Evolutionary immunology
  • Comparative immunology
  • Metazoan phylogeny

Background:

  • Mammalian immune system research distinguishes between adaptive and innate immune recognition.
  • Experimental access to non-mammalian vertebrates and invertebrates offers new insights.
  • Understanding immune molecule emergence and receptor diversification is crucial.

Purpose of the Study:

  • To explore the evolutionary patterns of immune molecules across metazoan phylogeny.
  • To investigate alternative mechanisms for immune receptor diversification.
  • To re-evaluate traditional distinctions between innate and adaptive immunity.

Main Methods:

  • Comparative analysis of immune systems in diverse animal groups.
  • Phylogenetic studies of immune-related molecules.

Related Experiment Videos

  • Examination of receptor diversification mechanisms in non-mammalian species.

    • Main Results:

    • Findings suggest immune system evolution is more complex than previously thought.
    • Alternative receptor diversification mechanisms exist beyond those in mammals.
    • Blurring of traditional adaptive and innate immunity distinctions observed.

    Conclusions:

    • The immune system has evolved diverse solutions for host protection throughout metazoan history.
    • Comparative studies reveal a broader range of immune strategies across the animal kingdom.
    • Traditional classifications of immunity may oversimplify evolutionary processes.