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Landiolol attenuates the cardiovascular response to tracheal intubation
Toru Goyagi1, Makoto Tanaka, Toshiaki Nishikawa
1Department of Anesthesiology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Purpose:
The objective of this prospective study was to compare the cardiovascular responses with or without landiolol to the induction of general anesthesia and tracheal intubation.
Methods:
Twenty-two patients were randomly allocated to receive a loading dose of landiolol 125 microg kg(-1) min(-1) for 1 min followed by an infusion at 40 microg kg(-1) min(-1) for 4 min, or placebo. Four minutes after landiolol or placebo was started, propofol and succinylcholine were administered. Laryngoscopy and tracheal intubation were performed 1 min after the administration of succinylcholine. Heart rate and blood pressure were measured noninvasively every minute.
Results:
A significant attenuation of the heart rate and blood pressure response were seen in the landiolol group for 3 min after intubation. Heart rate and systolic blood pressure in the landiolol group were decreased for 2 min before intubation and just before intubation compared with baseline, respectively.
Conclusion:
Continuous administration of landiolol before tracheal intubation results in the attenuation of cardiovascular response for tracheal intubation.
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