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Quantifying CBF with pulsed ASL: technical and pulse sequence factors.

Eric C Wong1

  • 1University of California, San Diego, La Jolla, California CA 92093-0677, USA. ecwong@ucsd.edu

Journal of Magnetic Resonance Imaging : JMRI
|November 2, 2005
PubMed
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This study reviews pulsed arterial spin labeling (ASL) for quantifying cerebral blood flow (CBF). It highlights technical challenges and introduces velocity-selective ASL (VS-ASL) as a promising method for accurate CBF measurement.

Area of Science:

  • Medical Imaging
  • Neuroscience
  • Biophysics

Background:

  • Cerebral blood flow (CBF) is a critical physiological parameter.
  • Accurate CBF quantification is essential for diagnosing and monitoring neurological conditions.
  • Pulsed arterial spin labeling (ASL) is a non-invasive MRI technique for CBF measurement.

Purpose of the Study:

  • To summarize current methods for CBF quantification using pulsed ASL.
  • To discuss technical challenges impacting CBF quantitation accuracy.
  • To introduce novel ASL techniques, such as velocity-selective ASL (VS-ASL).

Main Methods:

  • Review of existing pulsed ASL techniques for CBF measurement.
  • Discussion of technical limitations: transit delay, RF slice profiles, magnetization transfer, tagging efficiency, and geometry.

Related Experiment Videos

  • Introduction of Velocity-Selective ASL (VS-ASL) utilizing velocity-based tagging.

    • Main Results:

    • Pulsed ASL methods face several challenges in accurate CBF quantitation.
    • Various tagging schemes and pulse sequence modifications exist to address these challenges.
    • VS-ASL offers a potential solution for CBF measurement insensitive to transit delays.

    Conclusions:

    • Accurate CBF quantification with pulsed ASL requires careful consideration of technical factors.
    • VS-ASL represents a significant advancement, potentially overcoming transit delay limitations in ASL.
    • Further research into VS-ASL is warranted for improved clinical application.