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Arterial spin labeling: validity testing and comparison studies.

James R Ewing1, Yue Cao, Robert A Knight

  • 1Department of Neurology, Henry Ford Health Systems, Detroit, Michigan 48202, USA. jre@neurnis.neuro.hfh.edu

Journal of Magnetic Resonance Imaging : JMRI
|November 2, 2005
PubMed
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Arterial spin labeling (ASL) accurately measures cerebral blood flow (CBF) changes, even at high rates. However, ASL imaging systematically overestimates absolute CBF values by 34% compared to quantitative autoradiography.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Arterial spin labeling (ASL) offers quantitative cerebral blood flow (CBF) imaging.
  • Validation of ASL in animal models using gold-standard methods is limited.
  • Radiolabeled water methods can underestimate CBF in high-flow states, an effect not previously observed in ASL.

Purpose of the Study:

  • To model and experimentally validate the accuracy of ASL measurements for cerebral blood flow (CBF).
  • To specifically assess ASL performance under high-flow conditions.
  • To investigate potential overestimation of CBF by ASL.

Main Methods:

  • Developed a model for the ASL signal, incorporating intravascular labeled spins.
  • Performed modeling to assess ASL signal linearity with respect to baseline and changing flow rates.

Related Experiment Videos

  • Conducted validation studies in a rat model of unilateral cerebral ischemia using quantitative autoradiography (QAR).

    • Main Results:

    • ASL signal modeling demonstrated linearity with respect to baseline flow and flow changes, including high-flow states.
    • Experimental validation using QAR in a rat ischemia model revealed a systematic ASL overestimation of CBF by 34%.
    • Modeling predicted a similar overestimation of CBF by ASL.

    Conclusions:

    • ASL signals exhibit linear behavior with respect to flow, even under high-flow conditions.
    • ASL-derived CBF measurements are systematically overestimated.
    • Further calibration or correction methods may be necessary for accurate absolute CBF quantification using ASL.