Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Putaminal gray matter volume decrease in panic disorder: an optimized voxel-based morphometry study.

Hanik K Yoo1, Minue J Kim, Seog Ju Kim

  • 1Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

The European Journal of Neuroscience
|November 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MEGF8 controls osteogenic differentiation through post-transcriptional regulation of BMP-SMAD signaling in craniosynostosis.

Cell death and differentiation·2026
Same author

TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity.

Signal transduction and targeted therapy·2026
Same author

Identification of distinct clinical phenotypes and their neurobiological signatures in stress-exposed individuals: A multimodal machine learning approach.

European psychiatry : the journal of the Association of European Psychiatrists·2026
Same author

Association between PTSD symptoms and sigma power during stage 2 sleep in North Korean refugees with traumatic experience.

Acta psychologica·2026
Same author

CRISPR-Cpf1-Mediated Gene-Editing System Based on a Single Bidirectional Promoter.

International journal of molecular sciences·2026
Same author

Sensorimotor network hyperactivity and impaired psychomotor performance associated with cumulative occupational stress in firefighters.

Brain research bulletin·2026
Same journal

Hyperthyroidism Is Genetically Associated With Reduced Risk of Parkinson's Disease: A Mendelian Randomization Analysis.

The European journal of neuroscience·2026
Same journal

How Precise Is Predictive Coding for Things We Hear? Mismatch Negativity With Shepard Tones.

The European journal of neuroscience·2026
Same journal

Can Neuroscience Inform Peacebuilding?

The European journal of neuroscience·2026
Same journal

Game-Based Foreign-Language Speech Rehearsal Improves Pitch Processing Beyond Speech Domain.

The European journal of neuroscience·2026
Same journal

Sleep Oscillations Across Cortical, Subcortical and Cerebellar Structures in Magnetoencephalography.

The European journal of neuroscience·2026
Same journal

Freezing of Gait Levodopa Response Pattern in Parkinson's Disease Provides Clues to Pathophysiology.

The European journal of neuroscience·2026
See all related articles

This study found reduced gray matter volume in the putamen of panic disorder patients compared to healthy individuals. This finding may link structural brain changes to panic disorder severity.

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroanatomy

Background:

  • Panic disorder is a common psychiatric condition.
  • Previous research suggests structural brain abnormalities in panic disorder.
  • Voxel-based morphometry (VBM) is a neuroimaging technique used to study regional brain volume differences.

Purpose of the Study:

  • To investigate gray matter volume differences between patients with panic disorder and healthy volunteers.
  • To explore the relationship between gray matter volume and clinical severity in panic disorder.

Main Methods:

  • Optimized voxel-based morphometry (VBM) was employed.
  • 18 patients with panic disorder and 18 healthy volunteers participated.
  • Gray matter volumes were compared between groups.

Related Experiment Videos

  • Panic Disorder Severity Scale (PDSS) and Zung Self-Rating Anxiety Scale (Z-SAS) were administered.

    • Main Results:

    • Significantly decreased gray matter volume was observed in the bilateral putamen of panic disorder patients compared to healthy controls (corrected P < 0.05).
    • Additional reductions in gray matter volume were noted in the right precuneus, right inferior temporal gyrus, right inferior frontal gyrus, left superior temporal gyrus, and left superior frontal gyrus.
    • Negative correlations were found between PDSS scores and gray matter volume in the left putamen, right putamen, right inferior frontal gyrus, and left superior frontal gyrus.
    • Illness duration negatively correlated with left putaminal gray matter volume.
    • Z-SAS scores negatively correlated with right putaminal gray matter volume.

    Conclusions:

    • The study identifies reduced gray matter volume in the putamen as a potential neuroanatomical marker in panic disorder.
    • These putaminal gray matter reductions may be associated with the clinical severity and anxiety symptoms of panic disorder.