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Detection of an mRNA polymorphism by differential display
Shan Liang1, S Paul Rossby, Peng Liang
1Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA.
Abstract:
Differential display technology was utilized to compare programs of gene expression in primary cultures of human skin fibroblasts from normal volunteers and patients diagnosed with melancholic depression. Polymorphic transcripts of a single gene differing by one tandem repeat sequence of four nucleotides (TGAT) in the 3' noncoding region were detected.
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