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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Absolute configuration of TPU-0043, a pentaene macrolide from Streptomyces sp
Yasuhiro Igarashi1, Yasuko In, Toshimasa Ishida
1Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
The Journal of Antibiotics
|November 4, 2005
Abstract:
An antifungal pentaene macrolide TPU-0043 was isolated from Streptomyces sp. TP-A0625. The absolute configuration of TPU-0043 was determined to be 2R-(n-butyl)-16-methyl-3S,5S,7S,9R,11R,13R,15S,26S, 27R-nonahydroxyoctacosa-16,18,20,22,24-pentaenoic acid, 27-lactone, by X-ray crystallography of its 13-p-bromobenzenesulfonyl derivative.
