Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CREB, synapses and memory disorders: past progress and future challenges.

Sheena A Josselyn1, Peter V Nguyen

  • 1Program in Integrative Biology and Brain & Behaviour, Hospital for Sick Children Research Institute, 555 University Ave., Toronto, ON, Canada M5G 1X8. Sheena.josselyn@sickkids.ca

Current Drug Targets. CNS and Neurological Disorders
|November 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of major Ptchd1 isoforms causes autistic traits in social behavior and communication.

Molecular psychiatry·2026
Same author

Temporally gated offline engram ensemble reverberation in the lateral amygdala is required for fear memory consolidation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Microglia-dependent regulation of fear memory extinction.

Nature neuroscience·2026
Same author

Engrams and Memory: My Scientific "Eras Tour".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Neuronal competition shapes the encoding, consolidation, and retrieval of precise spatial memories in mice.

Current biology : CB·2026
Same author

Distinct CA1 inputs support shifts in neural dimensionality and memory resolution.

bioRxiv : the preprint server for biology·2026
Same journal

Partial QSAR analysis of some selected natural inhibitors of FAAH suggests a working hypothesis for the development of endocannabinoid-based drugs.

Current drug targets. CNS and neurological disorders·2005
Same journal

Therapeutic perspectives of inhibitors of endocannabinoid degradation.

Current drug targets. CNS and neurological disorders·2005
Same journal

Pharmacological properties and therapeutic possibilities for drugs acting upon endocannabinoid receptors.

Current drug targets. CNS and neurological disorders·2005
Same journal

Cannabinoids: between neuroprotection and neurotoxicity.

Current drug targets. CNS and neurological disorders·2005
Same journal

From cannabis to endocannabinoids in multiple sclerosis: a paradigm of central nervous system autoimmune diseases.

Current drug targets. CNS and neurological disorders·2005
Same journal

Endocannabinoids in neuroimmunology and stress.

Current drug targets. CNS and neurological disorders·2005
See all related articles

The cAMP responsive element binding protein (CREB) is crucial for long-term memory and neural functions. Research explores targeting CREB for cognitive disorder treatments and advancing understanding of neural plasticity.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Neurons convert external stimuli into intracellular signals for adaptation.
  • Gene expression regulation is vital for many neural functions.
  • cAMP responsive element binding protein (CREB) is a transcription factor regulating genes with CRE sites.

Purpose of the Study:

  • To review CREB-dependent transcription.
  • To evaluate CREB's role in neural plasticity and long-term memory.
  • To explore CREB as a therapeutic target for cognitive disorders.

Main Methods:

  • Literature review of studies on CREB in invertebrates and vertebrates.
  • Analysis of CREB's role in long-term facilitation in Aplysia.
  • Examination of CREB's function in hippocampal long-term potentiation (LTP).

Related Experiment Videos

Main Results:

  • CREB is critical for long-term memory across species.
  • CREB plays a role in synaptic plasticity, including LTP.
  • Altered CREB-regulated gene expression is linked to human cognitive disorders.

Conclusions:

  • CREB is a key regulator of neural plasticity and memory formation.
  • Targeting CREB offers potential therapeutic strategies for cognitive impairments.
  • Further research is needed to advance understanding and applications of CREB function.