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Long-term tolerability study of Voltaren.
1Department of Orthopaedics, Faculty of Medicine, Branch Hospital, Nagoya University, Japan.
The Journal of International Medical Research
|January 1, 1975
Summary
Voltaren, an anti-inflammatory and analgesic, demonstrated excellent long-term safety in clinical trials. This study indicates Voltaren is safe for prolonged use in chronic conditions without impacting key bodily functions.
Area of Science:
- Pharmacology
- Clinical Medicine
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- Long-term tolerability of NSAIDs is a significant clinical concern.
Purpose of the Study:
- To evaluate the long-term safety and tolerability of Voltaren (diclofenac sodium).
- To assess the effects of Voltaren on hematological, hepatic, and renal functions during extended treatment.
Main Methods:
- A clinical study involving 13 patients treated with Voltaren for 110 to 559 days.
- Regular laboratory investigations including blood counts, liver enzymes (SGOT, SGPT), alkaline phosphatase, and urinalysis were performed.
Main Results:
- No adverse effects were observed that could be attributed to long-term Voltaren treatment.
- Voltaren did not negatively impact hematopoiesis, hepatic function, or renal function in the study cohort.
Conclusions:
- Voltaren is a safe anti-inflammatory and analgesic agent for long-term therapy.
- The drug is suitable for managing chronic diseases requiring extended anti-inflammatory and analgesic treatment.