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[In vitro transdermal permeation of lidocaine-dodecanol binary eutectic system]
Guang-ming Ke1, Li Wang, Ping Wang
1College of Science, Beijing University of Chemical Technology, Beijing 100029, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|November 5, 2005
Summary
The lidocaine-dodecanol eutectic system significantly enhances lidocaine transdermal permeation. This novel formulation increases drug flux sixfold compared to pure lidocaine patches.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Physical Chemistry
Context:
- Transdermal drug delivery offers a non-invasive alternative to conventional administration routes.
- Lidocaine is a widely used local anesthetic with limitations in transdermal bioavailability.
- Eutectic systems are explored to improve drug solubility and permeation.
Purpose:
- To investigate the impact of a lidocaine-dodecanol binary eutectic system on lidocaine transdermal permeation.
- To develop and characterize transdermal patches incorporating this eutectic system.
- To compare the transdermal flux of lidocaine from eutectic system patches versus pure lidocaine patches.
Summary:
- Binary eutectic mixtures of lidocaine and dodecanol were prepared and formulated into transdermal patches.
- Solubility studies in pH 7.9 phosphate buffer were conducted.
- Franz-type diffusion cells were used to measure transdermal flux, revealing a six-fold increase with the eutectic system compared to pure lidocaine.
Impact:
- The lidocaine-dodecanol binary eutectic system demonstrates potential for enhanced transdermal drug delivery.
- This system achieves higher thermodynamic activity, increasing the driving force for lidocaine permeation.
- Results suggest improved efficacy and patient compliance for transdermal lidocaine formulations.