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Effect of endotoxin on cultured chinchilla middle ear epithelium
A Nakamura1, T F DeMaria, C van Blitterswijk
1Department of Otolaryngology, Ohio State University College of Medicine, Columbus.
The Annals of Otology, Rhinology, and Laryngology
|July 1, 1992
Abstract:
The effect of endotoxin on the growth and morphology of cultured chinchilla middle ear epithelium was examined. Within 24 hours of culture, cells maintained in medium containing endotoxin exhibited dose-dependent morphological changes. The highest concentration of endotoxin (100 mg) resulted in cell death. The growth curve of the cells in culture demonstrated a dose-dependent, significant increase in cell number when endotoxin was added to the medium.