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[Biochemical modulation--the historical background].

¹Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|July 1, 1992

Summary

Biochemical modulation enhances anticancer drug effectiveness and manages side effects. Historically, combinations like methotrexate (MTX) and 5-fluorouracil (5-FU) proved effective for gastric cancer, a principle still relevant today.

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Area of Science:

Oncology
Pharmacology
Biochemistry

Context:

Biochemical modulation involves altering anticancer drug efficacy or side effects.
Historical combination therapy of methotrexate (MTX) and 5-fluorouracil (5-FU) demonstrated effectiveness in advanced gastric cancer.
Current research explores 5-FU or fluoropyrimidines combined with cisplatin (CDDP) for digestive organ cancers.

Purpose:

To review the concept and historical application of biochemical modulation in cancer therapy.
To highlight the underlying biochemical or pharmacological modulation in effective drug combinations.

Summary:

Biochemical modulation is key to optimizing anticancer drug treatments.
Effective combination therapies, such as MTX/5-FU and 5-FU/CDDP, rely on these modulatory principles.
This approach has historical significance and ongoing relevance in treating various cancers.

Impact:

Understanding biochemical modulation can lead to improved cancer treatment strategies.
Optimizing drug combinations enhances therapeutic outcomes and potentially reduces side effects.
This principle underpins the development of more effective chemotherapeutic regimens.

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