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Peptic Ulcer

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...

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Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
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Pulmonary Tuberculosis III

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Peptic Ulcer Disease V: Surgical Management and Nursing Care

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Peptic Ulcer Disease I: Introduction

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Updated: May 18, 2026

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Buruli ulcer in a nine-month-old boy.

S Tsukagoshi¹, T C B Dehn

¹Oxford Deanery, UK. tsukagoshi@doctors.org.uk

Annals of the Royal College of Surgeons of England

|October 4, 2012

Summary

Buruli ulcer, a neglected tropical disease, requires early diagnosis and treatment with rifampicin and streptomycin to prevent progression. Surgery may be necessary for complex cases, as seen in a Ugandan infant with forearm ulcers.

Area of Science:

Tropical medicine
Infectious diseases
Dermatology

Background:

Buruli ulcer diagnosis and treatment pose challenges in tropical rural settings.
Established tuberculosis programs can aid in managing Buruli ulcer.

Observation:

A nine-month-old infant in Uganda presented with multiple ulcers on the right forearm.
The case was observed by visiting British surgeons in a district hospital.

Findings:

Painless, undermined ulcers in the tropics warrant consideration for Buruli ulcer.
Prompt initiation of rifampicin and streptomycin is crucial for halting and potentially reversing disease progression.
Surgery is reserved for complex ulcers or those with complications.

Implications:

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Last Updated: May 18, 2026

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Early recognition and management of Buruli ulcer are vital, especially in resource-limited areas.
Integration with existing health programs, like tuberculosis control, could improve Buruli ulcer outcomes.
This case highlights the need for accessible diagnostics and treatment for Buruli ulcer in endemic regions.